Concomitant abnormalities in Brugada syndrome

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Sinus node dysfunction concomitant with Brugada syndrome.

BACKGROUND A genetic correlation between Brugada syndrome (BS) and sinus node dysfunction (SND) has been proposed, although the clinical and electrophysiologic characteristics of this concomitant condition are unknown. METHODS AND RESULTS The study comprised 5 patients with symptomatic BS (4 with spontaneous episodes of ventricular fibrillation (VF) and 1 with syncope) of whom 3 had a documen...

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Inferior and lateral electrocardiographic repolarization abnormalities in Brugada syndrome.

BACKGROUND Repolarization abnormalities in the inferior-lateral leads in Brugada syndrome (BS) have not been systematically investigated. METHODS AND RESULTS 280 patients (age, 41+/-18 years; 168 males) with BS were screened for inferior-lateral repolarization abnormalities. The repolarization abnormalities were classified either as early repolarization pattern or coved > or = 2-mm Brugada pa...

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Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome

BACKGROUND The right ventricular outflow tract (RVOT) is acknowledged to be responsible for arrhythmogenesis in Brugada syndrome (BrS), but the pathophysiology remains controversial. OBJECTIVES This study assessed the substrate underlying BrS at post-mortem and in vivo, and the role for open thoracotomy ablation. METHODS Six whole hearts from male post-mortem cases of unexplained sudden dea...

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Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome

Atrial fibrillation (AF) is most prevalent in cardiac arrhythmic disease. It may be the first presenting manifestation in certain cases, such as Brugada syndrome (BrS) and WolffParkinson-White (WPW) syndrome. BrS is an inherited cardiac arrhythmic disorder characterized electrocardiographically by coved-type ST-segment elevation in the right precordial leads (V1–V3). 1 Patients with BrS are sus...

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Brugada syndrome.

Brugada syndrome is a rare cardiac arrhythmia characterized by electrocardiographic right bundle branch block and persistent ST-segment elevation in the right precordial leads. It is associated with ventricular fibrillation and a high risk for sudden cardiac death, predominantly in younger males with structurally normal hearts. Patients can remain asymptomatic, and electrocardiographic patterns...

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ژورنال

عنوان ژورنال: Journal of Arrhythmia

سال: 2013

ISSN: 1880-4276

DOI: 10.1016/j.joa.2012.12.007